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DNA gyrase with a single catalytic tyrosine can catalyze DNA supercoiling by a nicking-closing mechanism

The topological state of DNA is important for replication, recombination and transcription, and is regulated in vivo by DNA topoisomerases. Gyrase introduces negative supercoils into DNA at the expense of ATP hydrolysis. It is the accepted view that gyrase achieves supercoiling by a strand passage m...

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Foilsithe in:Nucleic Acids Res
Main Authors: Gubaev, Airat, Weidlich, Daniela, Klostermeier, Dagmar
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137430/
https://ncbi.nlm.nih.gov/pubmed/27557712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw740
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