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Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage
Tyrosyl DNA phosphodiesterase 2 (TDP2) is a multifunctional protein implicated in DNA repair, signal transduction and transcriptional regulation. In its DNA repair role, TDP2 safeguards genome integrity by hydrolyzing 5′-tyrosyl DNA adducts formed by abortive topoisomerase II (Top2) cleavage complex...
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| Publicat a: | Nucleic Acids Res |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5137425/ https://ncbi.nlm.nih.gov/pubmed/27543075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw719 |
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