PKCδ null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth

OBJECTIVES: A key clinical paradox in osteoarthritis (OA), a prevalent age-related joint disorder characterised by cartilage degeneration and debilitating pain, is that the severity of joint pain does not strictly correlate with radiographic and histological defects in joint tissues. Here, we determ...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Kc, Ranjan, Li, Xin, Kroin, Jeffrey S, Liu, Zhiqiang, Chen, Di, Xiao, Guozhi, Levine, Brett, Li, Jinyuan, Hamilton, John L, van Wijnen, Andre J, Piel, Margaret, Shelly, Daniel A, Brass, Dovrat, Kolb, Ela, Im, Hee-Jeong
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136703/
https://ncbi.nlm.nih.gov/pubmed/26783110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-208444
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