Identification of a point mutation in type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet membrane glycoprotein Ib-IX receptor.

von Willebrand factor (vWF) supports platelet adhesion on thrombogenic surfaces by binding to platelet membrane glycoprotein (GP) Ib in the GP Ib-IX receptor complex. This interaction is physiologically regulated so that it does not occur between circulating vWF and platelets but, rather, only at a...

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Bibliographische Detailangaben
Hauptverfasser: Ware, J, Dent, J A, Azuma, H, Sugimoto, M, Kyrle, P A, Yoshioka, A, Ruggeri, Z M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1991
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC51357/
https://ncbi.nlm.nih.gov/pubmed/2011604
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