Identification of a point mutation in type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet membrane glycoprotein Ib-IX receptor.

von Willebrand factor (vWF) supports platelet adhesion on thrombogenic surfaces by binding to platelet membrane glycoprotein (GP) Ib in the GP Ib-IX receptor complex. This interaction is physiologically regulated so that it does not occur between circulating vWF and platelets but, rather, only at a...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ware, J, Dent, J A, Azuma, H, Sugimoto, M, Kyrle, P A, Yoshioka, A, Ruggeri, Z M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51357/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2011604/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.7.2946
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