Lycorine Downregulates HMGB1 to Inhibit Autophagy and Enhances Bortezomib Activity in Multiple Myeloma

Multiple myeloma (MM) is largely incurable and drug-resistant. Novel therapeutic approaches such as inhibiting autophagy or rational drug combinations are aimed to overcome this issue. In this study, we found that lycorine exhibits a promising anti-proliferative activity against MM in vitro and in v...

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Vydáno v:Theranostics
Hlavní autoři: Roy, Mridul, Liang, Long, Xiao, Xiaojuan, Peng, Yuanliang, Luo, Yuhao, Zhou, Weihua, Zhang, Ji, Qiu, Lugui, Zhang, Shuaishuai, Liu, Feng, Ye, Mao, Zhou, Wen, Liu, Jing
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135444/
https://ncbi.nlm.nih.gov/pubmed/27924158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.15584
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