NMR detection of intermolecular interaction sites in the dimeric 5′-leader of the HIV-1 genome

HIV type-1 (HIV-1) contains a pseudodiploid RNA genome that is selected for packaging and maintained in virions as a noncovalently linked dimer. Genome dimerization is mediated by conserved elements within the 5′-leader of the RNA, including a palindromic dimer initiation signal (DIS) that has been...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Keane, Sarah C., Van, Verna, Frank, Heather M., Sciandra, Carly A., McCowin, Sayo, Santos, Justin, Heng, Xiao, Summers, Michael F.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135362/
https://ncbi.nlm.nih.gov/pubmed/27791166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614785113
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