SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity

The 3C-like protease (3CL(pro)) of severe acute respiratory syndrome coronavirus (SARS-CoV) cleaves 11 sites in the polyproteins, including its own N- and C-terminal autoprocessing sites, by recognizing P4–P1 and P1′. In this study, we determined the crystal structure of 3CL(pro) with the C-terminal...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Muramatsu, Tomonari, Takemoto, Chie, Kim, Yong-Tae, Wang, Hongfei, Nishii, Wataru, Terada, Takaho, Shirouzu, Mikako, Yokoyama, Shigeyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135343/
https://ncbi.nlm.nih.gov/pubmed/27799534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601327113
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