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SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity
The 3C-like protease (3CL(pro)) of severe acute respiratory syndrome coronavirus (SARS-CoV) cleaves 11 sites in the polyproteins, including its own N- and C-terminal autoprocessing sites, by recognizing P4–P1 and P1′. In this study, we determined the crystal structure of 3CL(pro) with the C-terminal...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5135343/ https://ncbi.nlm.nih.gov/pubmed/27799534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601327113 |
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