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IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans

Hepatic fibrosis arises from inflammation in the liver initiated by resident macrophage activation and massive leukocyte accumulation. Hepatic macrophages hold a central position in maintaining homeostasis in the liver and in the pathogenesis of acute and chronic liver injury linked to fibrogenesis....

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Alzaid, Fawaz, Lagadec, Floriane, Albuquerque, Miguel, Ballaire, Raphaëlle, Orliaguet, Lucie, Hainault, Isabelle, Blugeon, Corinne, Lemoine, Sophie, Lehuen, Agnès, Saliba, David G., Udalova, Irina A., Paradis, Valérie, Foufelle, Fabienne, Venteclef, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135279/
https://ncbi.nlm.nih.gov/pubmed/27942586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88689
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