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α-Linoleic Acid Enhances the Capacity of α1-Antitrypsin to Inhibit Lipopolysaccharide-Induced IL-1β in Human Blood Neutrophils

Alpha1-antitrypsin (A1AT, SERPINA1), a major circulating inhibitor of neutrophil elastase (NE) and proteinase-3 (PR3), has been proposed to reduce the processing and release of IL-1β. Since the antiinflammatory properties of A1AT are influenced by the presence of polyunsaturated fatty acids, we comp...

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Detalhes bibliográficos
Publicado no:Mol Med
Main Authors: Aggarwal, Nupur, Korenbaum, Elena, Mahadeva, Ravi, Immenschuh, Stephan, Grau, Veronika, Dinarello, Charles A, Welte, Tobias, Janciauskiene, Sabina
Formato: Artigo
Idioma:Inglês
Publicado em: Feinstein Institute for Medical Research 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135082/
https://ncbi.nlm.nih.gov/pubmed/27452044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2016.00119
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