Polymers of Z α(1)-Antitrypsin Co-Localize with Neutrophils in Emphysematous Alveoli and Are Chemotactic in Vivo

The molecular mechanisms that cause emphysema are complex but most theories suggest that an excess of proteinases is a crucial requirement. This paradigm is exemplified by severe deficiency of the key anti-elastase within the lung: α(1)-antitrypsin. The Z mutant of α(1)-antitrypsin has a point mutat...

Full description

Saved in:
Bibliographic Details
Main Authors: Mahadeva, Ravi, Atkinson, Carl, Li, Zhenjun, Stewart, Susan, Janciauskiene, Sabina, Kelley, Diane G., Parmar, Jasvir, Pitman, Rebecca, Shapiro¶, Steven D., Lomas, David A.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2005
Subjects:
Original Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278851/
https://ncbi.nlm.nih.gov/pubmed/15681822
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items