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Opsin spectral sensitivity determines the effectiveness of optogenetic termination of ventricular fibrillation in the human heart: a simulation study

KEY POINTS: Optogenetics‐based defibrillation, a theoretical alternative to electrotherapy, involves expression of light‐sensitive ion channels in the heart (via gene or cell therapy) and illumination of the cardiac surfaces (via implanted LED arrays) to elicit light‐induced activations. We used a b...

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Vydáno v:J Physiol
Hlavní autoři: Karathanos, Thomas V., Bayer, Jason D., Wang, Dafang, Boyle, Patrick M., Trayanova, Natalia A.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5134403/
https://ncbi.nlm.nih.gov/pubmed/26941055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271739
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