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Opsin spectral sensitivity determines the effectiveness of optogenetic termination of ventricular fibrillation in the human heart: a simulation study

KEY POINTS: Optogenetics‐based defibrillation, a theoretical alternative to electrotherapy, involves expression of light‐sensitive ion channels in the heart (via gene or cell therapy) and illumination of the cardiac surfaces (via implanted LED arrays) to elicit light‐induced activations. We used a b...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Karathanos, Thomas V., Bayer, Jason D., Wang, Dafang, Boyle, Patrick M., Trayanova, Natalia A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5134403/
https://ncbi.nlm.nih.gov/pubmed/26941055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271739
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