Peroxisome proliferator‐activated receptor‐γ coactivator 1 α1 induces a cardiac excitation–contraction coupling phenotype without metabolic remodelling

KEY POINTS: Transcriptional co‐activator PGC‐1α1 has been shown to regulate energy metabolism and to mediate metabolic adaptations in pathological and physiological cardiac hypertrophy but other functional implications of PGC‐1α1 expression are not known. Transgenic PGC‐1α1 overexpression within the...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Mutikainen, Maija, Tuomainen, Tomi, Naumenko, Nikolay, Huusko, Jenni, Smirin, Boris, Laidinen, Svetlana, Kokki, Krista, Hynynen, Heidi, Ylä‐Herttuala, Seppo, Heinäniemi, Merja, Ruas, Jorge L., Tavi, Pasi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5134381/
https://ncbi.nlm.nih.gov/pubmed/27716916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272847
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