Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-κB

Sirtuin 1 (Sirt1) is a deacetylase that regulates many cellular processes in the liver, and so far its role in endotoxemic liver injury is elusive. So we conditionally inactivate Sirt1 in murine hepatocytes to determine its role in d-galactosamine (GalN)/lipopolysaccharide (LPS)-induced liver damage...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Cui, Xiaolan, Chen, Qian, Dong, Zhen, Xu, Longmei, Lu, Tianfei, Li, Dawei, Zhang, Jiangjun, Zhang, Ming, Xia, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133964/
https://ncbi.nlm.nih.gov/pubmed/27711079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.270
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