AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells

AMP-activated protein kinase (AMPK), a biological sensor for cellular energy status, has been shown to act upstream and downstream of known tumour suppressors. However, whether AMPK itself plays a tumor suppressor role in cancer remains unclear. Here, we found that the α2 catalytic subunit isoform o...

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Bibliografiske detaljer
Main Authors: Lee, Chi-Wai, Wong, Leo Lap-Yan, Tse, Edith Yuk-Ting, Liu, Heong-Fai, Leong, Veronica Yee-Law, Man-Fong, Joyce, Hardie, D. Grahame, Ng, Irene Oi-Lin, Ching, Yick-Pang
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433393/
https://ncbi.nlm.nih.gov/pubmed/22728651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-0429
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