miR-27a attenuates adipogenesis and promotes osteogenesis in steroid-induced rat BMSCs by targeting PPARγ and GREM1

The imbalance between adipogenic and osteogenic differentiation in bone marrow mesenchymal stem cells (BMSCs) plays a significant role in the pathogenesis of steroid-induced osteonecrosis of the femoral head (ONFH). Several microRNAs (miRNAs) are involved in regulating adipogenesis and osteogenesis....

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Publicado en:Sci Rep
Main Authors: Gu, Chenxi, Xu, Yan, Zhang, Shanfeng, Guan, Hongya, Song, Shi, Wang, Xiuli, Wang, Yisheng, Li, Yuebai, Zhao, Guoqiang
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133594/
https://ncbi.nlm.nih.gov/pubmed/27910957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38491
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