SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradation

SAG/RBX2 and RBX1 are two family members of RING components of Cullin-RING ligases (CRLs), required for their enzymatic activity. Previous studies showed that SAG prefers to bind with CUL5, as well as CUL1, whereas RBX1 binds exclusively to CULs1–4. Detailed biochemical difference between SAG and RB...

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Sparad:
Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Kuang, Peng, Tan, Mingjia, Zhou, Weihua, Zhang, Qiang, Sun, Yi
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133542/
https://ncbi.nlm.nih.gov/pubmed/27910872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37441
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