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Using gene expression data to identify causal pathways between genotype and phenotype in a complex disease: application to Genetic Analysis Workshop 19

We explore causal relationships between genotype, gene expression and phenotype in the Genetic Analysis Workshop 19 data. We compare the use of structural equation modeling and a Bayesian unified framework approach to infer the most likely causal models that gave rise to the data. Testing an exhaust...

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Detalhes bibliográficos
Publicado no:BMC Proc
Main Authors: Ainsworth, Holly F., Cordell, Heather J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133478/
https://ncbi.nlm.nih.gov/pubmed/27980615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12919-016-0009-x
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