Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements

Dynamic redefinition of the 10 UGAs in human and mouse selenoprotein P (Sepp1) mRNAs to specify selenocysteine instead of termination involves two 3′ UTR structural elements (SECIS) and is regulated by selenium availability. In addition to the previously known human Sepp1 mRNA poly(A) addition site...

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Dades bibliogràfiques
Publicat a:Open Biol
Autors principals: Wu, Sen, Mariotti, Marco, Santesmasses, Didac, Hill, Kristina E., Baclaocos, Janinah, Aparicio-Prat, Estel, Li, Shuping, Mackrill, John, Wu, Yuanyuan, Howard, Michael T., Capecchi, Mario, Guigó, Roderic, Burk, Raymond F., Atkins, John F.
Format: Artigo
Idioma:Inglês
Publicat: The Royal Society 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133445/
https://ncbi.nlm.nih.gov/pubmed/27881738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160241
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