Prostatic Acid Phosphatase Alters the RANKL/OPG System and Induces Osteoblastic Prostate Cancer Bone Metastases

Prostate cancer (PCa) is unique in its tendency to produce osteoblastic (OB) bone metastases. There are no existing therapies that specifically target the OB phase that affects 90% of men with bone metastatic disease. Prostatic acid phosphatase (PAP) is secreted by PCa cells in OB metastases and inc...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Kirschenbaum, Alexander, Izadmehr, Sudeh, Yao, Shen, O'Connor-Chapman, Kieley L., Huang, Alan, Gregoriades, Elias M., Yakar, Shoshana, Levine, Alice C.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2016
Assuntos:
Rapid Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133341/
https://ncbi.nlm.nih.gov/pubmed/27783536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1606
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