α(7)-nAChR agonist enhances neural plasticity in the hippocampus via a GABAergic circuit

Agonists of the α(7)-nicotinic acetylcholine receptor (α(7)-nAChR) have entered clinical trials as procognitive agents for treating schizophrenia and Alzheimer's disease. The most advanced compounds are orthosteric agonists, which occupy the ligand binding site. At the molecular level, agonist...

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Detalhes bibliográficos
Publicado no:J Neurophysiol
Main Authors: Townsend, Matthew, Whyment, Andrew, Walczak, Jean-Sebastien, Jeggo, Ross, van den Top, Marco, Flood, Dorothy G., Leventhal, Liza, Patzke, Holger, Koenig, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
Assuntos:
Neural Circuits
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133305/
https://ncbi.nlm.nih.gov/pubmed/27655963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00243.2016
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