α(7)-nAChR agonist enhances neural plasticity in the hippocampus via a GABAergic circuit

Agonists of the α(7)-nicotinic acetylcholine receptor (α(7)-nAChR) have entered clinical trials as procognitive agents for treating schizophrenia and Alzheimer's disease. The most advanced compounds are orthosteric agonists, which occupy the ligand binding site. At the molecular level, agonist...

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Dades bibliogràfiques
Publicat a:J Neurophysiol
Autors principals: Townsend, Matthew, Whyment, Andrew, Walczak, Jean-Sebastien, Jeggo, Ross, van den Top, Marco, Flood, Dorothy G., Leventhal, Liza, Patzke, Holger, Koenig, Gerhard
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2016
Matèries:
Neural Circuits
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133305/
https://ncbi.nlm.nih.gov/pubmed/27655963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00243.2016
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