Unraveling the pharmacokinetic interaction of ticagrelor and MEDI2452 (Ticagrelor antidote) by mathematical modeling

The investigational ticagrelor‐neutralizing antibody fragment, MEDI2452, is developed to rapidly and specifically reverse the antiplatelet effects of ticagrelor. However, the dynamic interaction of ticagrelor, the ticagrelor active metabolite (TAM), and MEDI2452, makes pharmacokinetic (PK) analysis...

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Publicat a:CPT Pharmacometrics Syst Pharmacol
Autors principals: Almquist, J, Penney, M, Pehrsson, S, Sandinge, A‐S, Janefeldt, A, Maqbool, S, Madalli, S, Goodman, J, Nylander, S, Gennemark, P
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5131888/
https://ncbi.nlm.nih.gov/pubmed/27310493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12089
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