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Local cellular and cytokine cues in the spleen regulate in situ T cell receptor affinity as well as function and fate of CD8(+) T cells

T cells rapidly undergo contraction upon viral clearance, but how T cell function and fate are determined during this phase is unclear. During the contraction phase of an acute infection with lymphocytic choriomeningitis virus, we found that virus-specific CD8(+) T cells within the splenic red pulp...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Seo, Young-Jin, Jothikumar, Prithiviraj, Suthar, Mehul S., Zhu, Cheng, Grakoui, Arash
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5131716/
https://ncbi.nlm.nih.gov/pubmed/27851926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.10.024
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