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Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates
The ability to revitalize and re-purpose existing drugs offers a powerful approach for novel treatment options against Mycobacterium tuberculosis and other infectious agents. Antifolates are an underutilized drug class in tuberculosis (TB) therapy, capable of disrupting the biosynthesis of tetrahydr...
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| Publicado en: | Sci Rep |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5131483/ https://ncbi.nlm.nih.gov/pubmed/27905500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38083 |
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