Methionine Antagonizes para-Aminosalicylic Acid Activity via Affecting Folate Precursor Biosynthesis in Mycobacterium tuberculosis

para-Aminosalicylic acid (PAS) is a second-line anti-tubercular drug that is used for the treatment of drug-resistant tuberculosis (TB). PAS efficacy in the treatment of TB is limited by its lower potency against Mycobacterium tuberculosis relative to many other drugs in the TB treatment arsenal. It...

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Bibliographic Details
Published in:Front Cell Infect Microbiol
Main Authors: Howe, Michael D., Kordus, Shannon L., Cole, Malcolm S., Bauman, Allison A., Aldrich, Courtney C., Baughn, Anthony D., Minato, Yusuke
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Cellular and Infection Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240602/
https://ncbi.nlm.nih.gov/pubmed/30483484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2018.00399
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