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In silico Mapping of Protein Unfolding Mutations for Inherited Disease

The effect of disease-causing missense mutations on protein folding is difficult to evaluate. To understand this relationship, we developed the unfolding mutation screen (UMS) for in silico evaluation of the severity of genetic perturbations at the atomic level of protein structure. The program take...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: McCafferty, Caitlyn L., Sergeev, Yuri V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5131339/
https://ncbi.nlm.nih.gov/pubmed/27905547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37298
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