Targeting Mechanotransduction at the Transcriptional Level: YAP and BRD4 Are Novel Therapeutic Targets for the Reversal of Liver Fibrosis

Liver fibrosis is the result of a deregulated wound healing process characterized by the excessive deposition of extracellular matrix. Hepatic stellate cells (HSCs), which are activated in response to liver injury, are the major source of extracellular matrix and drive the wound healing process. How...

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書目詳細資料
發表在:Front Pharmacol
Main Authors: Zhubanchaliyev, Altynbek, Temirbekuly, Aibar, Kongrtay, Kuralay, Wanshura, Leah C., Kunz, Jeannette
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2016
主題:
Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5131002/
https://ncbi.nlm.nih.gov/pubmed/27990121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00462
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