Lactobacillus acidophilus counteracts inhibition of NHE3 and DRA expression and alleviates diarrheal phenotype in mice infected with Citrobacter rodentium

Impaired absorption of electrolytes is a hallmark of diarrhea associated with inflammation or enteric infections. Intestinal epithelial luminal membrane NHE3 (Na(+)/H(+) exchanger 3) and DRA (Down-Regulated in Adenoma; Cl(−)/HCO(3)(−) exchanger) play key roles in mediating electroneutral NaCl absorp...

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Veröffentlicht in:Am J Physiol Gastrointest Liver Physiol
Hauptverfasser: Kumar, Anoop, Anbazhagan, Arivarasu N., Coffing, Hayley, Chatterjee, Ishita, Priyamvada, Shubha, Gujral, Tarunmeet, Saksena, Seema, Gill, Ravinder K., Alrefai, Waddah A., Borthakur, Alip, Dudeja, Pradeep K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2016
Schlagworte:
Inflammation, Immunity, Fibrosis, and Infection
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130543/
https://ncbi.nlm.nih.gov/pubmed/27634011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00173.2016
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