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Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals
Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by mutations in Frataxin (FXN). Loss of FXN causes impaired mitochondrial function and iron homeostasis. An elevated production of reactive oxygen species (ROS) was previously proposed to contribute to the pathogen...
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| Izdano u: | eLife |
|---|---|
| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
eLife Sciences Publications, Ltd
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5130293/ https://ncbi.nlm.nih.gov/pubmed/27901468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.20732 |
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