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Frataxin knockdown causes loss of cytoplasmic iron–sulfur cluster functions, redox alterations and induction of heme transcripts
Frataxin protein deficiency causes the neurodegenerative disease Friedreich ataxia. We used inducible siRNA to order the consequences of frataxin deficiency that we and others have previously observed. The earliest consequence of frataxin deficiency was a defect in cytoplasmic iron–sulfur proteins....
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1847786/ https://ncbi.nlm.nih.gov/pubmed/17098208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2006.09.010 |
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