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Methylation of Breast Cancer Predisposition Genes in Early-Onset Breast Cancer: Australian Breast Cancer Family Registry

DNA methylation can mimic the effects of both germline and somatic mutations for cancer predisposition genes such as BRCA1 and p16(INK4a). Constitutional DNA methylation of the BRCA1 promoter has been well described and is associated with an increased risk of early-onset breast cancers that have BRC...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Scott, Cameron M., Joo, JiHoon Eric, O’Callaghan, Neil, Buchanan, Daniel D., Clendenning, Mark, Giles, Graham G., Hopper, John L., Wong, Ee Ming, Southey, Melissa C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130174/
https://ncbi.nlm.nih.gov/pubmed/27902704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165436
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