Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic

Dysfunctional apoptotic machinery is a hallmark feature of chronic lymphocytic leukemia (CLL). Accordingly, targeting apoptosis regulators has been proven a rational approach for CLL treatment. We show that CLL lymphocytes express high levels of XIAP, cIAP1, and cIAP2 compared to normal lymphocytes....

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Balakrishnan, Kumudha, Fu, Min, Onida, Francesco, Wierda, William G., Keating, Michael J., Gandhi, Varsha
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129945/
https://ncbi.nlm.nih.gov/pubmed/27223062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8462
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