De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas

About 20% hepatocellular carcinomas (HCCs) display wild-type β-catenin, enhanced Wnt signaling, hepatocyte dedifferentiation and bad outcome, suggesting a specific impact of Wnt signals on HCC stem/progenitor cells. To study Wnt-specific molecular pathways, cell fates and clinical outcome, we fine-t...

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Vydáno v:Oncotarget
Hlavní autoři: Mebarki, Sihem, Désert, Romain, Sulpice, Laurent, Sicard, Marie, Desille, Mireille, Canal, Frédéric, Schneider, Hélène Dubois-Pot, Bergeat, Damien, Turlin, Bruno, Bellaud, Pascale, Lavergne, Elise, Guével, Rémy Le, Corlu, Anne, Perret, Christine, Coulouarn, Cédric, Clément, Bruno, Musso, Orlando
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper: Gerotarget (Focus on Aging)
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129911/
https://ncbi.nlm.nih.gov/pubmed/27191501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9346
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