Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active β-catenin

Constitutive activation of Wnt/β-catenin signaling in cancer results from mutations in pathway components, which frequently coexist with autocrine Wnt signaling or epigenetic silencing of extracellular Wnt antagonists. Among the extracellular Wnt inhibitors, the secreted frizzled-related proteins (S...

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Main Authors: Lavergne, Elise, Hendaoui, Ismaïl, Coulouarn, Cédric, Ribault, Catherine, Leseur, Julie, Eliat, Pierre-Antoine, Mebarki, Sihem, Corlu, Anne, Clément, Bruno, Musso, Orlando
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501789/
https://ncbi.nlm.nih.gov/pubmed/20856206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.432
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