Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids

Cremastranone (1), a naturally occurring homoisoflavonoid, inhibited angiogenesis in vitro and in vivo. We developed an analogue SH-11037 (2) which is more potent than cremastranone in human retinal microvascular endothelial cells (HRECs) and blocks neovascularization in animal models. Despite its e...

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Bibliografiset tiedot
Julkaisussa:Bioorg Med Chem Lett
Päätekijät: Lee, Bit, Sun, Wei, Lee, Hyungjun, Basavarajappa, Halesha, Sulaiman, Rania S., Sishtla, Kamakshi, Fei, Xiang, Corson, Timothy W., Seo, Seung-Yong
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129841/
https://ncbi.nlm.nih.gov/pubmed/27481561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.07.043
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