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Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids
Cremastranone (1), a naturally occurring homoisoflavonoid, inhibited angiogenesis in vitro and in vivo. We developed an analogue SH-11037 (2) which is more potent than cremastranone in human retinal microvascular endothelial cells (HRECs) and blocks neovascularization in animal models. Despite its e...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5129841/ https://ncbi.nlm.nih.gov/pubmed/27481561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.07.043 |
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