Genotypes of CYP2C8 and FGD4 and their association with peripheral neuropathy or early dose reduction in paclitaxel-treated breast cancer patients

BACKGROUND: The purpose of this study was to evaluate single-nucleotide polymorphisms (SNPs) in genes encoding key metabolising enzymes or involved in pharmacodynamics for possible associations with paclitaxel-induced peripheral neuropathy. METHODS: The study population consists of 188 women from th...

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Enregistré dans:
Détails bibliographiques
Publié dans:Br J Cancer
Auteurs principaux: Lam, Siu W, Frederiks, Charlotte N, van der Straaten, Tahar, Honkoop, Aafke H, Guchelaar, Henk-Jan, Boven, Epie
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Translational Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129817/
https://ncbi.nlm.nih.gov/pubmed/27736846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.326
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