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CYP2C19 pharmacogenetics in advanced cancer: compromised function independent of genotype
CYP2C19 is a drug-metabolising enzyme involved in the metabolism of a number of chemotherapeutic agents including cyclophosphamide. Variants of the CYP2C19 gene result in a loss of function polymorphism, which affects approximately 3% of the Caucasian population. These individuals are poor metabolis...
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Main Authors: | , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2570511/ https://ncbi.nlm.nih.gov/pubmed/18854824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604699 |
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