The combined impact of CYP2C19 and CYP2B6 pharmacogenetics on cyclophosphamide bioactivation

AIMS: The role of CYP pharmacogenetics in the bioactivation of cyclophosphamide is still controversial. Recent clinical studies have suggested a role for either CYP2C19 or CYP2B6. The aim of this study was to clarify the role of these pharmacogenes. METHODS: We used a combined in vitro–in vivo appro...

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Detalhes bibliográficos
Main Authors: Helsby, Nuala A, Hui, Chung-Yee, Goldthorpe, Michael A, Coller, Janet K, Soh, May Ching, Gow, Peter J, de Zoysa, Janak Z, Tingle, Malcolm D
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Pharmacogenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014068/
https://ncbi.nlm.nih.gov/pubmed/21175440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03789.x
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