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Ketoisocaproic acid, a metabolite of leucine, suppresses insulin-stimulated glucose transport in skeletal muscle cells in a BCAT2-dependent manner
Although leucine has many positive effects on metabolism in multiple tissues, elevated levels of this amino acid and the other branched-chain amino acids (BCAAs) and their metabolites are implicated in obesity and insulin resistance. While some controversies exist about the direct effect of leucine...
Enregistré dans:
| Publié dans: | Am J Physiol Cell Physiol |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Physiological Society
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5129764/ https://ncbi.nlm.nih.gov/pubmed/27488662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00062.2016 |
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