Functional Genomics Identifies Tis21-Dependent Mechanisms and Putative Cancer Drug Targets Underlying Medulloblastoma Shh-Type Development

We have recently generated a novel medulloblastoma (MB) mouse model with activation of the Shh pathway and lacking the MB suppressor Tis21 (Patched1(+/−)/Tis21(KO)). Its main phenotype is a defect of migration of the cerebellar granule precursor cells (GCPs). By genomic analysis of GCPs in vivo, we...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Gentile, Giulia, Ceccarelli, Manuela, Micheli, Laura, Tirone, Felice, Cavallaro, Sebastiano
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127835/
https://ncbi.nlm.nih.gov/pubmed/27965576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00449
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