Structural Pliability Adjacent to the Kinase Domain Highlights Contribution of FAK1 IDRs to Cytoskeletal Remodeling

Therapeutic protein kinase inhibitors are designed on the basis of kinase structures. Here, we define intrinsically disordered regions (IDRs) in structurally hybrid kinases. We reveal that 65% of kinases have an IDR adjacent to their kinase domain (KD). These IDRs are evolutionarily more conserved t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochim Biophys Acta
Prif Awduron: Kathiriya, Jaymin J., Pathak, Ravi Ramesh, Bezginov, Alexandr, Xue, Bin, Uversky, Vladimir N., Tillier, Elisabeth R.M., Davé, Vrushank
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127739/
https://ncbi.nlm.nih.gov/pubmed/27718363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2016.10.002
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