Structural Pliability Adjacent to the Kinase Domain Highlights Contribution of FAK1 IDRs to Cytoskeletal Remodeling

Therapeutic protein kinase inhibitors are designed on the basis of kinase structures. Here, we define intrinsically disordered regions (IDRs) in structurally hybrid kinases. We reveal that 65% of kinases have an IDR adjacent to their kinase domain (KD). These IDRs are evolutionarily more conserved t...

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Détails bibliographiques
Publié dans:Biochim Biophys Acta
Auteurs principaux: Kathiriya, Jaymin J., Pathak, Ravi Ramesh, Bezginov, Alexandr, Xue, Bin, Uversky, Vladimir N., Tillier, Elisabeth R.M., Davé, Vrushank
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127739/
https://ncbi.nlm.nih.gov/pubmed/27718363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2016.10.002
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