High-Resolution Phenotypic Landscape of the RNA Polymerase II Trigger Loop

The active sites of multisubunit RNA polymerases have a “trigger loop” (TL) that multitasks in substrate selection, catalysis, and translocation. To dissect the Saccharomyces cerevisiae RNA polymerase II TL at individual-residue resolution, we quantitatively phenotyped nearly all TL single variants...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Qiu, Chenxi, Erinne, Olivia C., Dave, Jui M., Cui, Ping, Jin, Huiyan, Muthukrishnan, Nandhini, Tang, Leung K., Babu, Sabareesh Ganesh, Lam, Kenny C., Vandeventer, Paul J., Strohner, Ralf, Van den Brulle, Jan, Sze, Sing-Hoi, Kaplan, Craig D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127505/
https://ncbi.nlm.nih.gov/pubmed/27898685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006321
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