High-Resolution Phenotypic Landscape of the RNA Polymerase II Trigger Loop

The active sites of multisubunit RNA polymerases have a “trigger loop” (TL) that multitasks in substrate selection, catalysis, and translocation. To dissect the Saccharomyces cerevisiae RNA polymerase II TL at individual-residue resolution, we quantitatively phenotyped nearly all TL single variants...

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Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Qiu, Chenxi, Erinne, Olivia C., Dave, Jui M., Cui, Ping, Jin, Huiyan, Muthukrishnan, Nandhini, Tang, Leung K., Babu, Sabareesh Ganesh, Lam, Kenny C., Vandeventer, Paul J., Strohner, Ralf, Van den Brulle, Jan, Sze, Sing-Hoi, Kaplan, Craig D.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127505/
https://ncbi.nlm.nih.gov/pubmed/27898685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006321
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