Reduced high-frequency motor neuron firing, EMG fractionation, and gait variability in awake walking ALS mice

Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease prominently featuring motor neuron (MN) loss and paralysis. A recent study using whole-cell patch clamp recording of MNs in acute spinal cord slices from symptomatic adult ALS mice showed that the fastest firing MNs are prefer...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Hadzipasic, Muhamed, Ni, Weiming, Nagy, Maria, Steenrod, Natalie, McGinley, Matthew J., Kaushal, Adi, Thomas, Eleanor, McCormick, David A., Horwich, Arthur L.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2016
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127366/
https://ncbi.nlm.nih.gov/pubmed/27821773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616832113
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