ERK activation globally downregulates miRNAs through phosphorylating exportin-5

MicroRNAs (miRNA) are mostly downregulated in cancer. However, the mechanism underlying this phenomenon and the precise consequence in tumorigenesis remain obscure. Here we show that ERK suppresses pre-miRNA export from the nucleus through phosphorylation of exportin-5 (XPO5) at T345/S416/S497. Afte...

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Publicado no:Cancer Cell
Main Authors: Sun, Hui-Lung, Cui, Ri, Zhou, JianKang, Teng, Kun-yu, Hsiao, Yung-Hsuan, Nakanishi, Kotaro, Fassan, Matteo, Luo, Zhenghua, Shi, Guqin, Tili, Esmerina, Kutay, Huban, Lovat, Francesca, Vicentini, Caterina, Huang, Han-Li, Wang, Shih-Wei, Kim, Taewan, Zanesi, Nicola, Jeon, Young-Jun, Lee, Tae Jin, Guh, Jih-Hwa, Hung, Mien-Chie, Ghoshal, Kalpana, Teng, Che-Ming, Peng, Yong, Croce, Carlo M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127275/
https://ncbi.nlm.nih.gov/pubmed/27846390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.10.001
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