GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment

BACKGROUND: The aim of this study was to investigate the effect of downregulating Hedgehog pathway by GANT61 on human glioma cells, examine the consequent changes of temozolomide (TMZ)-induced effects and explore the molecular mechanisms. METHODS: The cytotoxicity of a Gli1/2 inhibitor, GANT61 was e...

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Publicado en:J Exp Clin Cancer Res
Autores principales: Li, Jianlong, Cai, Jinquan, Zhao, Shihong, Yao, Kun, Sun, Ying, Li, Yongli, Chen, Lingchao, Li, Ruiyan, Zhai, Xiuwei, Zhang, Junhe, Jiang, Chuanlu
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127098/
https://ncbi.nlm.nih.gov/pubmed/27894350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0463-3
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