Targeting cancer cell metabolism: The combination of metformin and 2-Deoxyglucose regulates apoptosis in ovarian cancer cells via p38 MAPK/JNK signaling pathway

Targeting cancer cell metabolism is a new promising strategy to fight cancer. Metformin, a first-line treatment for type 2 diabetes mellitus, exerts anti-cancer and anti-proliferative action. 2-deoxyglucose (2-DG), a glucose analog, works as a competitive inhibitor of glycolysis. In this study, we s...

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Bibliographic Details
Published in:Am J Transl Res
Main Authors: Zhu, Jie, Zheng, Ya, Zhang, Haiyan, Sun, Hong
Format: Artigo
Language:Inglês
Published: e-Century Publishing Corporation 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5126324/
https://ncbi.nlm.nih.gov/pubmed/27904682
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