Smart nanocrystals of artemether: fabrication, characterization, and comparative in vitro and in vivo antimalarial evaluation

Artemether (ARTM) is a very effective antimalarial drug with poor solubility and consequently low bioavailability. Smart nanocrystals of ARTM with particle size of 161±1.5 nm and polydispersity index of 0.172±0.01 were produced in <1 hour using a wet milling technology, Dena(®) DM-100. The crysta...

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Vydáno v:Drug Des Devel Ther
Hlavní autoři: Shah, Syed Muhammad Hassan, Ullah, Farhat, Khan, Shahzeb, Shah, Syed Muhammad Mukarram, de Matas, Marcel, Hussain, Zahid, Minhas, Muhammad Usman, AbdEl-Salam, Naser M, Assi, Khaled Hafez, Isreb, Mohammad
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125812/
https://ncbi.nlm.nih.gov/pubmed/27920499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S114962
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