TGFbeta Induces Binucleation/Polyploidization in Hepatocytes through a Src-Dependent Cytokinesis Failure

In all mammals, the adult liver shows binucleated as well as mononucleated polyploid hepatocytes. The hepatic polyploidization starts after birth with an extensive hepatocyte binucleation and generates hepatocytes of several ploidy classes. While the functional significance of hepatocyte polyploidy...

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Publicat a:PLoS One
Autors principals: De Santis Puzzonia, Marco, Cozzolino, Angela Maria, Grassi, Germana, Bisceglia, Francesca, Strippoli, Raffaele, Guarguaglini, Giulia, Citarella, Franca, Sacchetti, Benedetto, Tripodi, Marco, Marchetti, Alessandra, Amicone, Laura
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125678/
https://ncbi.nlm.nih.gov/pubmed/27893804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167158
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